Adrenocorticotropic hormone (ACTH) is a pituitary peptide hormone that stimulates cortisol release from the adrenal cortex. The 4–7 fragment of ACTH, which is the basis for Semax, has cognitive and neuroprotective properties separate from adrenal stimulation.

Semax — Research Peptide Definition

Q: Is Semax similar to Selank?

Both are Russian-developed peptides with CNS focus, but their mechanisms differ. Semax is based on ACTH fragments and primarily researched for neuroprotection. Selank is based on tuftsin and studied for anxiolytic effects.

Semax

Semax (ACTH 4-7 Analog)

Research Use Only · Not for Human Consumption

Semax is a synthetic heptapeptide based on the 4–7 fragment of adrenocorticotropic hormone (ACTH), specifically the sequence Met-Glu-His-Phe, extended with Pro-Gly-Pro to increase its stability and CNS activity. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax has been studied in preclinical and clinical models for neuroprotective effects, BDNF upregulation, and cognitive performance in ischemia models.

Key Facts

Based on: ACTH 4–7 fragment
Amino acid count: 7
CNS effect studied: Neuroprotection, BDNF
Storage: -20°C lyophilized

Research Applications

Neuroprotection research in ischemia models
BDNF and NGF upregulation studies
Cognitive enhancement models
ACTH fragment pharmacology
Stroke recovery research models

Frequently Asked Questions

What is ACTH?

Is Semax similar to Selank?

Stock Semax on Your Research Compound Store

PeptiCommerce provides turn-key access to COA-documented research compounds. Your branded WooCommerce store with P2P and crypto payment support, ready in under 72 hours.

Get Started →

Semax

Key Facts

Research Applications

Frequently Asked Questions

Related Terms

Get the Research Peptide Business Playbook