Peptide Bond
Peptide Bond (Amide Bond)
Research Use Only · Not for Human Consumption
A peptide bond (also called an amide bond) is the covalent bond that links amino acid residues together in a peptide or protein chain. It is formed by a condensation reaction between the carboxyl group (-COOH) of one amino acid and the amino group (-NH2) of the next, releasing a water molecule. The peptide bond has partial double-bond character due to resonance, which restricts rotation around the C-N bond and creates the planar peptide unit that gives proteins their secondary structure (alpha helices, beta sheets).
Key Facts
- Bond type
- Amide (C-N) bond
- Formation reaction
- Condensation (releases H₂O)
- Character
- Partial double bond due to resonance
- UV absorption
- At ~214 nm (used in HPLC detection)
Research Applications
- Understanding peptide synthesis principles
- Basis for HPLC UV detection of peptides
- Understanding peptide stability and degradation
- Protein structure research foundation
Frequently Asked Questions
Related Terms
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