Alpha-MSH (alpha-melanocyte-stimulating hormone) is an endogenous peptide derived from POMC (proopiomelanocortin) that regulates melanogenesis, inflammation, and energy homeostasis through melanocortin receptors.

Melanotan II — Research Peptide Definition

Q: Is Melanotan II the same as PT-141?

No. PT-141 (Bremelanotide) is derived from MT-II but has structural differences that alter its receptor selectivity and reduce skin pigmentation effects relative to MT-II.

Melanotan II

Melanotan II (MT-II)

Research Use Only · Not for Human Consumption

Melanotan II (MT-II) is a synthetic cyclic analog of alpha-melanocyte-stimulating hormone (α-MSH). It non-selectively activates multiple melanocortin receptor subtypes (MC1R, MC3R, MC4R, MC5R). MT-II was originally developed to study UV-independent melanogenesis (skin darkening) and has since been used broadly in melanocortin receptor pharmacology research.

Key Facts

Type: Cyclic α-MSH analog
Receptors: MC1R, MC3R, MC4R, MC5R
Amino acids: 7 (cyclic)
Storage: -20°C lyophilized

Research Applications

Melanogenesis and pigmentation research
Melanocortin receptor pharmacology
CNS appetite and metabolic signaling research
Arousal pathway studies

Frequently Asked Questions

Is Melanotan II the same as PT-141?

What is alpha-MSH?

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Melanotan II

Key Facts

Research Applications

Frequently Asked Questions

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